Diagnosis and molecular characterization of rabies virus from a buffalo in China: a case report.

ABSTRACT:

Background

Rabies virus (RABV) can infect many different species of warm-blooded animals. Glycoprotein G plays a key role in viral pathogenicity and neurotropism, and includes antigenic domains that are responsible for membrane fusion and host cell receptor recognition.

Case presentation

A case of buffalo rabies in China was diagnosed by direct fluorescent antibody test, G gene reverse-transcriptase polymerase chain reaction, and RABV mouse inoculation test. Molecular characterization of the RABV was performed using DNA sequencing, phylogenetic analysis and amino acid sequence comparison based on the G gene from different species of animals.

Conclusion

The results confirmed that the buffalo with suspected rabies was infected by RABV, which was genetically closely rela

SUBMITTER: Zhang KS 

PROVIDER: S-EPMC3061937 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature