Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2.

ABSTRACT: It is fundamentally important that signaling gradients provide positional information to govern morphogenesis of multicellular organisms. Morphogen gradients can generate different cell types in specific spatial order at distinct threshold concentrations. However, it is largely unknown whether and how signaling gradients also control cell polarities by acting as global cues. Here, we show that Wnt signaling gradient provides directional information to a field of cells. Vangl2, a core component in planar cell polarity, forms Wnt-induced receptor complex with Ror2 to sense Wnt dosages. Wnts dose-dependently induce Vangl2 phosphorylation of serine/threonine residues and Vangl2 activities depend on its levels of phosphorylation. In the limb bud, Wnt5a signaling gradient controls limb elongatio

SUBMITTER: Gao B 

PROVIDER: S-EPMC3062198 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature