C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.

ABSTRACT: The total synthesis of C(20)-trifluoro-6(E),8(Z),11(Z),14(Z) 5-oxo-ETE is reported. This compound was designed as an ω-oxidation-resistant analog of 5-oxo-ETE that would be resistant to metabolism. The trifluoro derivative of 5-oxo-ETE stimulated calcium mobilization in neutrophils and desensitized these cells to subsequent exposure to 5-oxo-ETE.

SUBMITTER: Patel P 

PROVIDER: S-EPMC3062511 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature