Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome.

ABSTRACT:

Objective

To evaluate association with polycystic ovary syndrome (PCOS) of 295 variants in 39 genes central to metabolic insulin signaling and glycogen synthase kinase 3β (GSK-3β) regulation, followed by replication efforts.

Design

Case-control association study, with discovery and replication cohorts.

Setting

Subjects were recruited from reproductive endocrinology clinics, and controls were recruited from communities surrounding the University of Alabama at Birmingham and Erasmus Medical Center, Rotterdam.

Patient(s)

A total of 273 cases with PCOS and 173 control subjects in the discovery cohort; and 526 cases and 3,585 control subjects in the replication cohort. All subjects were caucasian.

Intervention(s)

Phenotypic and genotypic assessment.

Main o

SUBMITTER: Goodarzi MO 

PROVIDER: S-EPMC3062664 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature