Identification of secretory odontoblasts using DMP1-GFP transgenic mice.

ABSTRACT: Terminal differentiation of odontoblasts from dental papilla is a long process involving several intermediate steps and changes in the transcriptional profile and expression of proteins secreted by cells in the odontoblast lineage. Transgenic mouse lines in which GFP expression is under the control of tissue- and stage specific promoters have provided powerful experimental tools for identification and isolation of cells at specific stages of differentiation along a lineage. Our previous studies showed utilization of pOBCol3.6GFP and pOBCol2.3GFP animals for identification of odontoblasts at early and late stages of polarization respectively. In the present study we used the DMP1-GFP transgenic animal as an experimental model to examine its expression during the differentiation of odontobla

SUBMITTER: Balic A 

PROVIDER: S-EPMC3062740 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature