Layers of epistasis: genome-wide regulatory networks and network approaches to genome-wide association studies.

ABSTRACT: The conceptual foundation of the genome-wide association study (GWAS) has advanced unchecked since its conception. A revision might seem premature as the potential of GWAS has not been fully realized. Multiple technical and practical limitations need to be overcome before GWAS can be fairly criticized. But with the completion of hundreds of studies and a deeper understanding of the genetic architecture of disease, warnings are being raised. The results compiled to date indicate that risk-associated variants lie predominantly in noncoding regions of the genome. Additionally, alternative methodologies are uncovering large and heterogeneous sets of rare variants underlying disease. The fear is that, even in its fulfillment, the current GWAS paradigm might be incapable of dissecting all kinds

SUBMITTER: Cowper-Sal lari R 

PROVIDER: S-EPMC3062944 | biostudies-literature | 2011 Sep-Oct

REPOSITORIES: biostudies-literature