Gene expression profiling in neutrophils from children with polyarticular juvenile idiopathic arthritis.

ABSTRACT:

Objective

We have previously reported a defect in neutrophil activation in children with polyarticular juvenile idiopathic arthritis (JIA). The current study was undertaken to determine whether gene expression abnormalities persist in JIA in remission and to use systems biology analysis to elucidate pathologic pathways in polyarticular JIA.

Methods

We performed gene expression profiling on neutrophils from children with polyarticular JIA. Children were grouped according to disease status. We studied 14 children with active disease who were taking medication, 8 children with clinical remission of disease who were taking medication (CRM status), and 6 children with clinical remission of disease who were not taking medication (CR status). We also studied 13 healthy children who

SUBMITTER: Jarvis JN 

PROVIDER: S-EPMC3063001 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature