Human primary adipocytes exhibit immune cell function: adipocytes prime inflammation independent of macrophages.

ABSTRACT:

Background

Obesity promotes inflammation in adipose tissue (AT) and this is implicated in pathophysiological complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Although based on the classical hypothesis, necrotic AT adipocytes (ATA) in obese state activate AT macrophages (ATM) that then lead to a sustained chronic inflammation in AT, the link between human adipocytes and the source of inflammation in AT has not been in-depth and systematically studied. So we decided as a new hypothesis to investigate human primary adipocytes alone to see whether they are able to prime inflammation in AT.

Methods and results

Using mRNA expression, human preadipocytes and adipocytes express the cytokines/chemokines and their receptors, MHC II molecule genes a

SUBMITTER: Meijer K 

PROVIDER: S-EPMC3063154 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature