Differential expression of salivary proteins between susceptible and insecticide-resistant mosquitoes of Culex quinquefasciatus.

ABSTRACT:

Background

The Culex quinquefasciatus mosquito, a major pest and vector of filariasis and arboviruses in the tropics, has developed multiple resistance mechanisms to the main insecticide classes currently available in public health. Among them, the insensitive acetylcholinesterase (ace-1(R) allele) is widespread worldwide and confers cross-resistance to organophosphates and carbamates. Fortunately, in an insecticide-free environment, this mutation is associated with a severe genetic cost that can affect various life history traits. Salivary proteins are directly involved in human-vector contact during biting and therefore play a key role in pathogen transmission.

Methods and results

An original proteomic approach combining 2D-electrophoresis and mass spectrometry was adopted

SUBMITTER: Djegbe I 

PROVIDER: S-EPMC3063158 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature