Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study.

ABSTRACT:

Background

Recent investigations demonstrated many genetic contributions to the development of human age-related hearing impairment (ARHI), however, reports of factors associated with a reduction in the ARHI risk are rare. Folate metabolism is essential for cellular functioning. Despite the extensive investigations regarding the roles of folate metabolism related gene polymorphisms in the pathophysiology of complex diseases, such as cancer, cardio-cerebrovascular disease, and atherosclerosis, little is known about the association with ARHI. The aim of this study is to investigate the effects of the methionine synthase (MTR) A2756G and methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphisms on the risk of hearing impairment in middle-aged and elderly Japanese.

Method

SUBMITTER: Uchida Y 

PROVIDER: S-EPMC3063203 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature