JAK/STAT signaling and human in vitro myogenesis.

ABSTRACT:

Background

A population of satellite cells exists in skeletal muscle. These cells are thought to be primarily responsible for postnatal muscle growth and injury-induced muscle regeneration. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade has a crucial role in regulating myogenesis. In rodent skeletal muscle, STAT3 is essential for satellite cell migration and myogenic differentiation, regulating the expression of myogenic factors. The aim of the present study was to investigate and compare the expression profile of JAK/STAT family members, using cultured primary human skeletal muscle cells.

Results

Near confluent proliferating myoblasts were induced to differentiate for 1, 5 or 10 days. During these developmental stages, membe

SUBMITTER: Trenerry MK 

PROVIDER: S-EPMC3063215 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature