Gene expression profiles in stage I uterine serous carcinoma in comparison to grade 3 and grade 1 stage I endometrioid adenocarcinoma.

ABSTRACT:

Background

Endometrial cancer is the most common gynecologic malignancy in the developed countries. Clinical studies have shown that early stage uterine serous carcinoma (USC) has outcomes similar to early stage high grade endometrioid adenocarcinoma (EAC-G3) than to early stage low grade endometrioid adenocarcinoma (EAC-G1). However, little is known about the origin of these different clinical outcomes. This study applied the whole genome expression profiling to explore the expression difference of stage I USC (n = 11) relative to stage I EAC-G3 (n = 11) and stage I EAC-G1 (n = 11), respectively.

Methodology/principal finding

We found that the expression difference between USC and EAC-G3, as measured by the number of differentially expressed genes (DEGs), is consistently le

SUBMITTER: Mhawech-Fauceglia P 

PROVIDER: S-EPMC3063241 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature