Implication of snail in metabolic stress-induced necrosis.

ABSTRACT:

Background

Necrosis, a type of cell death accompanied by the rupture of the plasma membrane, promotes tumor progression and aggressiveness by releasing the pro-inflammatory and angiogenic cytokine high mobility group box 1. It is commonly found in the core region of solid tumors due to hypoxia and glucose depletion (GD) resulting from insufficient vascularization. Thus, metabolic stress-induced necrosis has important clinical implications for tumor development; however, its regulatory mechanisms have been poorly investigated.

Methodology/principal findings

Here, we show that the transcription factor Snail, a key regulator of epithelial-mesenchymal transition, is induced in a reactive oxygen species (ROS)-dependent manner in both two-dimensional culture of cancer cells, inclu

SUBMITTER: Kim CH 

PROVIDER: S-EPMC3063248 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature