β2-adrenergic receptor genotype and other variables that contribute to labor pain and progress.

ABSTRACT:

Background

β2-Adrenergic receptor (β2AR) activity influences labor. Its genotype affects the incidence of preterm delivery. We determined the effect of β2AR genotype on term labor progress and maternal pain.

Methods

We prospectively enrolled 150 nulliparous parturients in the third trimester and obtained sensory thresholds, demographic information, and DNA. Cervical dilation, pain scores, and labor management data were extracted with associated times. The association of genetic and demographic factors with labor was tested using mixed effects models.

Results

Parturients who express Gln at the 27 position of the β2AR had slower labor (P < 0.03). They progressed from 1-10 cm dilation in approximately 21 h compared with 14 h among other patients. Asian ethnicity, previou

SUBMITTER: Reitman E 

PROVIDER: S-EPMC3063327 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature