In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates.

ABSTRACT:

Objective

To determine whether sphingosine-1-phosphate (S1P), or the S1P mimetic FTY720 shields ovaries of adult female rhesus monkeys from damage caused by 15 Gy of targeted radiotherapy, allowing for the retention of long-term fertility, and to evaluate whether S1P protects human ovarian tissue (xenografted into mice) from radiation-induced damage.

Design

Research animal study.

Setting

Research laboratory and teaching hospital.

Patient(s)

Adult female rhesus macaques (8-14 years of age; n = 21) and two women (24 and 27 years of age) undergoing gynecologic surgery for benign reasons, after informed consent and approval.

Intervention(s)

None.

Main outcome measure(s)

Ovarian histologic analysis, ovarian reserve measurements, and fertility in mating

SUBMITTER: Zelinski MB 

PROVIDER: S-EPMC3063448 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature