Estimation of odds ratios of genetic variants for the secondary phenotypes associated with primary diseases.

ABSTRACT: Genetic association studies for binary diseases are designed as case-control studies: the cases are those affected with the primary disease and the controls are free of the disease. At the time of case-control collection, information about secondary phenotypes is also collected. Association studies of secondary phenotype and genetic variants have received a great deal of interest recently. To study the secondary phenotypes, investigators use standard regression approaches, where individuals with secondary phenotypes are coded as cases and those without secondary phenotypes are coded as controls. However, using the secondary phenotype as an outcome variable in a case-control study might lead to a biased estimate of odds ratios (ORs) for genetic variants. The secondary phenotype is associate

SUBMITTER: Wang J 

PROVIDER: S-EPMC3063504 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature