Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis.

ABSTRACT: Although the effects of commensal bacteria on intestinal immune development seem to be profound, it remains speculative whether the gut microbiota influences extraintestinal biological functions. Multiple sclerosis (MS) is a devastating autoimmune disease leading to progressive deterioration of neurological function. Although the cause of MS is unknown, microorganisms seem to be important for the onset and/or progression of disease. However, it is unclear how microbial colonization, either symbiotic or infectious, affects autoimmunity. Herein, we investigate a role for the microbiota during the induction of experimental autoimmune encephalomyelitis (EAE), an animal model for MS. Mice maintained under germ-free conditions develop significantly attenuated EAE compared with conventionally col

SUBMITTER: Lee YK 

PROVIDER: S-EPMC3063590 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature