Hyperglycaemia and infarct size in animal models of middle cerebral artery occlusion: systematic review and meta-analysis.

ABSTRACT: Poststroke hyperglycaemia (PSH) is common, has an unclear pathophysiology, and is associated with poor outcomes. Animal studies report conflicting findings. We systematically reviewed the effects of hyperglycaemia on infarct volume in middle cerebral artery occlusion (MCAO) models, generating weighted mean differences between groups using random effects models summarised as effect size (normalised to control group infarct volume as 100%) and 95% confidence interval. Of 72 relevant papers, 23 reported infarct volume. Studies involved 664 animals and 35 distinct comparisons. Hyperglycaemia was induced by either streptozotocin (STZ, 17 comparisons, n=303) or dextrose (18 comparisons, n=356). Hyperglycaemic animals had infarcts that were 94% larger, but STZ was associated with significantly gr

SUBMITTER: MacDougall NJ 

PROVIDER: S-EPMC3063635 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature