Sex- and age-specific differences in core body temperature of C57Bl/6 mice.

ABSTRACT: Gender-specific differences in longevity are reported across species and are mediated by mechanisms not entirely understood. In C57Bl/6 mice, commonly used in aging research, males typically outlive females. Since in these animals modest but prolonged reduction of core body (Tc) increased life span, we hypothesized that differential Tc may contribute to sex-specific longevity. Here, we compared the circadian profiles of Tc and locomotor activity (LMA) of male and female C57Bl/6 mice. Since Tc and LMA normally change with age, measurements were carried out in young (3 months) as well as in old (24 months) mice. In young females, Tc was influenced by estrous but was overall higher than in males. This difference was larger in old animals after age eliminated the variations associated with est

SUBMITTER: Sanchez-Alavez M 

PROVIDER: S-EPMC3063645 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature