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ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma.

ABSTRACT: DPC4 is known to mediate signals initiated by type beta transforming growth factor (TGFbeta) as well as by other TGFbeta superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFbeta receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.

SUBMITTER: Su GH 

PROVIDER: S-EPMC30640 | biostudies-literature | 2001 Mar

REPOSITORIES: biostudies-literature

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ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma.

Su G H GH   Bansal R R   Murphy K M KM   Montgomery E E   Yeo C J CJ   Hruban R H RH   Kern S E SE  

Proceedings of the National Academy of Sciences of the United States of America 20010301 6

DPC4 is known to mediate signals initiated by type beta transforming growth factor (TGFbeta) as well as by other TGFbeta superfamily ligands such as activin and BMP (bone morphogenic proteins), but mutational surveys of such non-TGFbeta receptors have been negative to date. Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene. ...[more]

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