Lifecourse childhood adiposity trajectories associated with adolescent insulin resistance.

ABSTRACT:

Objective

In light of the obesity epidemic, we aimed to characterize novel childhood adiposity trajectories from birth to age 14 years and to determine their relation to adolescent insulin resistance.

Research design and methods

A total of 1,197 Australian children with cardiovascular/metabolic profiling at age 14 years were studied serially from birth to age 14 years. Semiparametric mixture modeling was applied to anthropometric data over eight time points to generate adiposity trajectories of z scores (weight-for-height and BMI). Fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) were compared at age 14 years between adiposity trajectories.

Results

Seven adiposity trajectories were identified. Three (two rising and one chronic high adip

SUBMITTER: Huang RC 

PROVIDER: S-EPMC3064016 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature