The association between dietary sodium intake, ESRD, and all-cause mortality in patients with type 1 diabetes.

ABSTRACT:

Objective

Many guidelines recommend reduced consumption of salt in patients with type 1 diabetes, but it is unclear whether dietary sodium intake is associated with mortality and end-stage renal disease (ESRD).

Research design and methods

In a nationwide multicenter study (the FinnDiane Study) between 1998 and 2002, 2,807 enrolled adults with type 1 diabetes without ESRD were prospectively followed. Baseline urinary sodium excretion was estimated on a 24-h urine collection. The predictors of all-cause mortality and ESRD were determined by Cox regression and competing risk modeling, respectively.

Results

The median follow-up for survival analyses was 10 years, during which 217 deaths were recorded (7.7%). Urinary sodium excretion was nonlinearly associated with all-cau

SUBMITTER: Thomas MC 

PROVIDER: S-EPMC3064042 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature