Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy.

ABSTRACT:

Objective

To investigate the role of epigenetic regulation of the manganese superoxide dismutase gene (sod2) in the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression after hyperglycemia is terminated.

Research design and methods

Streptozotocin-induced diabetic rats were maintained in poor glycemic control (PC, GHb ∼12%) or in good glycemic control (GC, GHb ~7.0%) for 4 months, or were allowed to maintain PC for 2 months, followed by GC for 2 additional months (PC-Rev). For experimental galactosemia, a group of normal rats were fed a 30% galactose diet for 4 months or for 2 months, followed by a normal diet for 2 additional months. Trimethyl histone H4 lysine 20 (H4K20me3), acetyl histone H3 lysine 9 (H3K9), and

SUBMITTER: Zhong Q 

PROVIDER: S-EPMC3064104 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature