Inhibition of intestinal biotin absorption by chronic alcohol feeding: cellular and molecular mechanisms.

ABSTRACT: The water-soluble vitamin biotin is essential for normal cellular functions and its deficiency leads to a variety of clinical abnormalities. Mammals obtain biotin from exogenous sources via intestinal absorption, a process mediated by the sodium-dependent multivitamin transporter (SMVT). Chronic alcohol use in humans is associated with a significant reduction in plasma biotin levels, and animal studies have shown inhibition in intestinal biotin absorption by chronic alcohol feeding. Little, however, is known about the cellular and molecular mechanisms involved in the inhibition in intestinal biotin transport by chronic alcohol use. These mechanisms were investigated in this study by using rats and transgenic mice carrying the human full-length SLC5A6 5'-regulatory region chronically fed al

SUBMITTER: Subramanya SB 

PROVIDER: S-EPMC3064116 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature