Structure-function similarities between a plant receptor-like kinase and the human interleukin-1 receptor-associated kinase-4.

ABSTRACT: Phylogenetic analysis has previously shown that plant receptor-like kinases (RLKs) are monophyletic with respect to the kinase domain and share an evolutionary origin with the animal interleukin-1 receptor-associated kinase/Pelle-soluble kinases. The lysin motif domain-containing receptor-like kinase-3 (LYK3) of the legume Medicago truncatula shows 33% amino acid sequence identity with human IRAK-4 over the kinase domain. Using the structure of this animal kinase as a template, homology modeling revealed that the plant RLK contains structural features particular to this group of kinases, including the tyrosine gatekeeper and the N-terminal extension α-helix B. Functional analysis revealed the importance of these conserved features for kinase activity and suggests that kinase activity is es

SUBMITTER: Klaus-Heisen D 

PROVIDER: S-EPMC3064175 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature