Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome.

ABSTRACT:

Purpose

Steroid hormones and growth factors affect lung cancer, and it is possible they act in concert to influence patient outcome.

Experimental design

Primary lung tumors and normal lung tissue were analyzed for expression and localization of estrogen receptor α and β-1 (ERα and ERβ), aromatase, progesterone receptor (PR), and epidermal growth factor receptor (EGFR).

Results

Tumors expressed higher levels of ERβ compared to matched normal lung, whereas the reverse was true of PR. High cytoplasmic ERβ expression was identified as an independent negative prognostic predictor of overall survival (OS; HR = 1.67), and low total PR was identified as an independent negative predictor of time to progression (TTP; HR = 1.59). After adjusting for stage, age, sex, and smoking,

SUBMITTER: Stabile LP 

PROVIDER: S-EPMC3064257 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature