Endothelial nitric oxide modulates expression and processing of amyloid precursor protein.

ABSTRACT:

Rationale

the exact etiology of sporadic Alzheimer disease (AD) is unclear, but it is interesting that several cardiovascular risk factors are associated with higher incidence of AD. The link between these risk factors and AD has yet to be identified; however, a common feature is endothelial dysfunction, specifically, decreased bioavailability of nitric oxide (NO).

Objective

to determine the relationship between endothelial derived NO and the expression and processing of amyloid precursor protein (APP).

Methods and results

we used human brain microvascular endothelial cells to examine the role of NO in modulating APP expression and processing in vitro. Inhibition of endothelial nitric oxide synthase (eNOS) with the specific NOS inhibitor L-NAME (N(G)-nitro-l-arginine

SUBMITTER: Austin SA 

PROVIDER: S-EPMC3064266 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature