A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients.

ABSTRACT: Metastasis-related recurrence often occurs in hepatocellular carcinoma (HCC) patients who receive curative therapies. At present, it is challenging to identify patients with high risk of recurrence, which would warrant additional therapies. In this study, we sought to analyze a recently developed metastasis-related gene signature for its utility in predicting HCC survival, using 2 independent cohorts consisting of a total of 386 patients who received radical resection. Cohort 1 contained 247 predominantly HBV-positive cases analyzed with an Affymetrix platform, whereas cohort 2 contained 139 cases with mixed etiology analyzed with the NCI Oligo Set microarray platform. We employed a survival risk prediction algorithm with training, test, and independent cross-validation strategies and foun

SUBMITTER: Roessler S 

PROVIDER: S-EPMC3064515 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature