Body size, physical activity, and risk of triple-negative and estrogen receptor-positive breast cancer.

ABSTRACT:

Background

Triple-negative breast cancer, characterized by a lack of hormone receptor and HER2 expression, is associated with a particularly poor prognosis. Focusing on potentially modifiable breast cancer risk factors, we examined the relationship between body size, physical activity, and triple-negative disease risk.

Methods

Using data from 155,723 women enrolled in the Women's Health Initiative (median follow-up, 7.9 years), we assessed associations between baseline body mass index (BMI), BMI in earlier adulthood, waist and hip circumference, waist-hip ratio, recreational physical activity, and risk of triple-negative (n=307) and estrogen receptor-positive (ER+, n=2,610) breast cancers.

Results

Women in the highest versus lowest BMI quartile had 1.35-fold (95% CI,

SUBMITTER: Phipps AI 

PROVIDER: S-EPMC3064558 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature