Unexpected long-term protection of adult offspring born to high-fat fed dams against obesity induced by a sucrose-rich diet.

ABSTRACT:

Background

Metabolic and endocrine environment during early life is crucial for metabolic imprinting. When dams were fed a high fat diet (HF diet), rat offspring developed hypothalamic leptin resistance with lean phenotype when weaned on a normal diet. Interestingly, when grown on the HF diet, they appeared to be protected against the effects of HF diet as compared to offspring of normally fed dams. The mechanisms involved in the protective effect of maternal HF diet are unclear.

Methodology/principal findings

We thus investigated the impact of maternal high fat diet on offspring subjected to normal or high palatable diet (P diet) on metabolic and endocrine parameters. We compared offspring born to dams fed P or HF diet. Offspring born to dams fed control or P diet, when fed

SUBMITTER: Couvreur O 

PROVIDER: S-EPMC3064582 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature