Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma.

ABSTRACT: Current risk stratification schemas for medulloblastoma, based on combinations of clinical variables and histotype, fail to accurately identify particularly good- and poor-risk tumors. Attempts have been made to improve discriminatory power by combining clinical variables with cytogenetic data. We report here a pooled analysis of all previous reports of chromosomal copy number related to survival data in medulloblastoma. We collated data from previous reports that explicitly quoted survival data and chromosomal copy number in medulloblastoma. We analyzed the relative prognostic significance of currently used clinical risk stratifiers and the chromosomal aberrations previously reported to correlate with survival. In the pooled dataset metastatic disease, incomplete tumor resection and sever

SUBMITTER: McCabe MG 

PROVIDER: S-EPMC3064691 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature