Magnetization transfer helps detect intestinal fibrosis in an animal model of Crohn disease.

ABSTRACT:

Purpose

To determine the utility of magnetization transfer (MT) in the identification and quantification of intestinal fibrosis in a rat model of Crohn disease.

Materials and methods

The university committee on the use and care of animals approved this study (UCUCA 08592). Lewis rats injected subserosally with peptidoglycan-polysaccharide (PG-PS) develop bowel inflammation 1 day after laparotomy (early phase) and fibrosis starting 14 days after laparotomy (late phase). The authors performed 2.0-T magnetic resonance (MR) imaging in 25 rats injected with PG-PS and 13 injected with human serum albumin (HSA) (control animals). Imaging was performed before laparotomy and on a weekly basis thereafter for up to 28 days. The MT ratio in the bowel wall was calculated. Resected cecal

SUBMITTER: Adler J 

PROVIDER: S-EPMC3064818 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature