Comparative analysis of human matrix metalloproteinases: Emerging therapeutic targets in diseases.

ABSTRACT: The identification of specific target proteins for any diseased condition involves extensive characterization of the potentially involved proteins. Members of a protein family demonstrating comparable features may show certain unusual features when implicated in a pathological condition. Advancements in the field of computational biology and the use of various bioinformatics tools for analysis can aid researchers to comprehend their system of work in primary stages of research. This initial screening can help to reduce time and cost of testing and experimentation in laboratory. Human matrix metalloproteinase (MMP) family of endopeptidases is one such family of 23 members responsible for the remodeling of extracellular matrix (ECM) by degradation of the ECM proteins. Though their role has b

SUBMITTER: Jaiswal A 

PROVIDER: S-EPMC3064848 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature