The host range of gammaretroviruses and gammaretroviral vectors includes post-mitotic neural cells.

ABSTRACT:

Background

Gammaretroviruses and gammaretroviral vectors, in contrast to lentiviruses and lentiviral vectors, are reported to be restricted in their ability to infect growth-arrested cells. The block to this restriction has never been clearly defined. The original assessment of the inability of gammaretroviruses and gammaretroviral vectors to infect growth-arrested cells was carried out using established cell lines that had been growth-arrested by chemical means, and has been generalized to neurons, which are post-mitotic. We re-examined the capability of gammaretroviruses and their derived vectors to efficiently infect terminally differentiated neuroendocrine cells and primary cortical neurons, a target of both experimental and therapeutic interest.

Methodology/principal findin

SUBMITTER: Liu XH 

PROVIDER: S-EPMC3065480 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature