Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model.

ABSTRACT: F-actin networks are important structural determinants of cell shape and morphogenesis. They are regulated through a number of actin-binding proteins. The function of many of these proteins is well understood, but very little is known about how they cooperate and integrate their activities in cellular contexts. Here, we have focussed on the cellular roles of actin regulators in controlling filopodial dynamics. Filopodia are needle-shaped, actin-driven cell protrusions with characteristic features that are well conserved amongst vertebrates and invertebrates. However, existing models of filopodia formation are still incomplete and controversial, pieced together from a wide range of different organisms and cell types. Therefore, we used embryonic Drosophila primary neurons as one consistent

SUBMITTER: Goncalves-Pimentel C 

PROVIDER: S-EPMC3065487 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature