Protein-protein interaction networks suggest different targets have different propensities for triggering drug resistance.

ABSTRACT: Emergence of drug resistance is a major problem in the treatment of many diseases including tuberculosis. To tackle the problem from a wholistic perspective, it is essential to understand the molecular mechanisms by which bacteria acquire drug resistance using a systems approach. Availability of genome-scale data of expression profiles under different drug exposed conditions and protein-protein interactions, makes it feasible to reconstruct and analyze systems-level models. A number of proteins involved in different resistance mechanisms, referred to as the resistome are identified from literature. The interaction of the drug directly with the resistome is unable to explain most resistance processes adequately, including that of increased mutations in the target's binding site. We recently

SUBMITTER: Padiadpu J 

PROVIDER: S-EPMC3065591 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature