Modeling metabolic adjustment in Mycobacterium tuberculosis upon treatment with isoniazid.

ABSTRACT:

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Complex biological systems exhibit a property of robustness at all levels of organization. Through different mechanisms, the system tries to sustain stress such as due to starvation or drug exposure. To explore whether reconfiguration of the metabolic networks is used as a means to achieve robustness, we have studied possible metabolic adjustments in Mtb upon exposure to isoniazid (INH), a front-line clinical drug. The redundancy in the genome of M. tuberculosis (Mtb) makes it an attractive system to explore if alternate routes of metabolism exist in the bacterium. While the mechanism of action of INH is well studied, its effect on the overall metabolism is not well characterized. Using flux balance analysis, inhibiting the fluxes flowing through the reactions catalyzed

SUBMITTER: Bhat AG 

PROVIDER: S-EPMC3065594 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature