GOSSIP: a method for fast and accurate global alignment of protein structures.

ABSTRACT:

Motivation

The database of known protein structures (PDB) is increasing rapidly. This results in a growing need for methods that can cope with the vast amount of structural data. To analyze the accumulating data, it is important to have a fast tool for identifying similar structures and clustering them by structural resemblance. Several excellent tools have been developed for the comparison of protein structures. These usually address the task of local structure alignment, an important yet computationally intensive problem due to its complexity. It is difficult to use such tools for comparing a large number of structures to each other at a reasonable time.

Results

Here we present GOSSIP, a novel method for a global all-against-all alignment of any set of protein structures.

SUBMITTER: Kifer I 

PROVIDER: S-EPMC3065682 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature