A quantitative analysis of transmission efficiency versus intensity for malaria.

ABSTRACT: The relationship between malaria transmission intensity and efficiency is important for malaria epidemiology, for the design of randomized control trials that measure transmission or incidence as end points, and for measuring and modelling malaria transmission and control. Five kinds of studies published over the past century were assembled and reanalysed to quantify malaria transmission efficiency and describe its relation to transmission intensity, to understand the causes of inefficient transmission and to identify functions suitable for modelling mosquito-borne disease transmission. In this study, we show that these studies trace a strongly nonlinear relationship between malaria transmission intensity and efficiency that is parsimoniously described by a model of heterogeneous biting. W

SUBMITTER: Smith DL 

PROVIDER: S-EPMC3065713 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature