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Dataset Information

Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia.


ABSTRACT:

Background

The pathophysiology of auditory verbal hallucinations remains poorly understood.

Aims

To characterise the time course of regional brain activity leading to auditory verbal hallucinations.

Method

During functional magnetic resonance imaging, 11 patients with schizophrenia or schizoaffective disorder signalled auditory verbal hallucination events by pressing a button. To control for effects of motor behaviour, regional activity associated with hallucination events was scaled against corresponding activity arising from random button-presses produced by 10 patients who did not experience hallucinations.

Results

Immediately prior to the hallucinations, motor-adjusted activity in the left inferior frontal gyrus was significantly greater than corres

SUBMITTER: Hoffman RE 

PROVIDER: S-EPMC3065772 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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