Smoking and schizophrenia independently and additively reduce white matter integrity between striatum and frontal cortex.

ABSTRACT:

Background

Although schizophrenia patients are at high risk for tobacco use, the neurobiological basis of this comorbid association is not clear. White matter abnormalities have been described independently in schizophrenia and smoking cohorts. We sought to determine whether smoking and schizophrenia are associated with similar white matter abnormalities that could be biomarkers for the high risk of smoking in schizophrenia.

Methods

Whole brain white matter integrity (fractional anisotropy) was measured in 46 schizophrenia patients (32 smokers and 14 nonsmokers) and 69 healthy age-matched control subjects (48 smokers and 21 nonsmokers).

Results

Schizophrenia and smoking status were independently and additively associated with reduced fractional anisotropy in left ante

SUBMITTER: Zhang X 

PROVIDER: S-EPMC3065776 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature