D1 and D2 dopamine receptors differentially mediate the activation of phosphoproteins in the striatum of amphetamine-sensitized rats.

ABSTRACT:

Rationale

Extracellular signal-regulated kinase (ERK), cAMP response element binding protein (CREB), and protein kinase B (PKB or Akt) in the striatum are differentially activated by acute and repeated amphetamine (AMPH) administration. However, the dopamine receptor subtypes that mediate transient vs. prolonged phosphorylation changes in these proteins induced by AMPH challenge in AMPH-sensitized rats are unknown.

Objectives

The role of the D1 and D2 class of dopamine receptors in the differential phosphorylation of striatal ERK, CREB, Thr308-Akt and Ser473-Akt and the expression of behavioral sensitization induced by AMPH challenge in AMPH-pretreated rats were determined.

Methods

D1 or D2 dopamine receptor antagonists were injected before an AMPH challenge in AMPH-s

SUBMITTER: Shi X 

PROVIDER: S-EPMC3065836 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature