Patterns of baseline autonomic nerve activity and the development of pacing-induced sustained atrial fibrillation.

ABSTRACT:

Background

Whether autonomic nerve activity is important in the development of pacing-induced sustained atrial fibrillation (AF) is unclear.

Objective

The purpose of this study was to test the hypothesis that patterns of baseline autonomic nerve activity are important in the development of pacing-induced sustained AF.

Methods

Radiotransmitters were implanted in 12 ambulatory dogs to record left stellate ganglion nerve activity (SGNA) and vagal nerve activity (VNA). Sustained (>48 hours) AF was induced with intermittent rapid atrial pacing.

Results

At baseline (before pacing), 1-minute integrated nerve activity between SGNA and VNA demonstrated either a single linear relationship with excellent correlation (group 1, N = 3, r = 0.816 ± 0.105) or nonlinear relatio

SUBMITTER: Shen MJ 

PROVIDER: S-EPMC3065927 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature