Molecular profiles of drinking alcohol to intoxication in C57BL/6J mice.

ABSTRACT:

Background

Alcohol addiction develops through a series of stages, and mechanistic studies are needed to understand the transition from initial drug use to sustained controlled alcohol consumption followed by abuse and physical dependence. The focus of this study was to examine the effects of voluntary alcohol consumption on brain gene expression profiles using a mouse model of binge drinking. The main goal was to identify alcohol-responsive genes and functional categories after a single episode of drinking to intoxication.

Methods

We used a modification of a "Drinking In the Dark" (DID) procedure (Rhodes et al., 2005) that allows mice to experience physiologically relevant amounts of alcohol in a non-stressful environment and also allows for detection of alcohol-sensitive mo

SUBMITTER: Mulligan MK 

PROVIDER: S-EPMC3066294 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature