Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis.

ABSTRACT: The re-emergence of tuberculosis in its present-day manifestations - single, multiple and extensive drug-resistant forms and as HIV-TB coinfections - has resulted in renewed research on fundamental questions such as the nature of the organism itself, Mycobacterium tuberculosis, the molecular basis of its pathogenesis, definition of the immunological response in animal models and humans, and development of new intervention strategies such as vaccines and drugs. Foremost among these developments has been the precise chemical definition of the complex and distinctive cell wall of M. tuberculosis, elucidation of the relevant pathways and underlying genetics responsible for the synthesis of the hallmark moieties of the tubercle bacillus such as the mycolic acid-arabinogalactan-peptidoglycan com

SUBMITTER: Kaur D 

PROVIDER: S-EPMC3066434 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature