Task-dependent V1 responses in human retinitis pigmentosa.

ABSTRACT:

Purpose

During measurement with functional MRI (fMRI) during passive viewing, subjects with macular degeneration (MD) have a large unresponsive lesion projection zone (LPZ) in V1. fMRI responses can be evoked from the LPZ when subjects engage in a stimulus-related task. The authors report fMRI measurements on a different class of subjects, those with retinitis pigmentosa (RP), who have intact foveal vision but peripheral visual field loss.

Methods

The authors measured three RP subjects and two control subjects. fMRI was performed while the subjects viewed drifting contrast pattern stimuli. The subjects passively viewed the stimuli or performed a stimulus-related task.

Results

During passive viewing, the BOLD response in the posterior calcarine cortex of all RP subject

SUBMITTER: Masuda Y 

PROVIDER: S-EPMC3066597 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature