Hot spots of integrase genotypic changes leading to HIV-2 resistance to raltegravir.

ABSTRACT: We studied seven heavily pretreated HIV-2-infected patients exhibiting a virological failure while receiving a salvage raltegravir-containing regimen. At the time of virological failure, different resistance genetic pathways were observed: T97A-Y143C, Q148K, Q148R, G140S-Q148R, E92Q-Y143R-N155H, and T97A-N155H. Thus, despite a 40% difference in integrase genes between HIV-1 and HIV-2, the genetic pathways leading to raltegravir resistance are similar.

SUBMITTER: Charpentier C 

PROVIDER: S-EPMC3067093 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature