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Novel structural elements within the nonproteolytic clostridium botulinum type F toxin gene cluster.


ABSTRACT: We sequenced for the first time the complete neurotoxin gene cluster of a nonproteolytic Clostridium botulinum type F. The neurotoxin gene cluster contained a novel gene arrangement that, compared to other C. botulinum neurotoxin gene clusters, lacked the regulatory botR gene and contained an intergenic is element between its orfX2 and orfX3 genes.

SUBMITTER: Dover N 

PROVIDER: S-EPMC3067269 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature

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Novel structural elements within the nonproteolytic clostridium botulinum type F toxin gene cluster.

Dover N N   Barash J R JR   Hill K K KK   Detter J C JC   Arnon S S SS  

Applied and environmental microbiology 20101223 5


We sequenced for the first time the complete neurotoxin gene cluster of a nonproteolytic Clostridium botulinum type F. The neurotoxin gene cluster contained a novel gene arrangement that, compared to other C. botulinum neurotoxin gene clusters, lacked the regulatory botR gene and contained an intergenic is element between its orfX2 and orfX3 genes. ...[more]

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