Integrative expression system for delivery of antibody fragments by lactobacilli.

ABSTRACT: A series of expression cassettes which mediate secretion or surface display of antibody fragments was stably integrated in the chromosome of Lactobacillus paracasei. L. paracasei producing surface-anchored variable domain of llama heavy chain (VHH) (ARP1) directed against rotavirus showed efficient binding to rotavirus and protection in the mouse model of rotavirus infection.

SUBMITTER: Martin MC 

PROVIDER: S-EPMC3067310 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature