Cholesterol is not an essential source of nutrition for Mycobacterium tuberculosis during infection.

ABSTRACT: Rv1106c (hsd; 3β-hydroxysteroid dehydrogenase) is required by Mycobacterium tuberculosis for growth on cholesterol as a sole carbon source, whereas Rv3409c is not. Mutation of Rv1106c does not reduce Mycobacterium tuberculosis growth in infected macrophages or guinea pigs. We conclude that cholesterol is not required as a nutritional source during infection.

SUBMITTER: Yang X 

PROVIDER: S-EPMC3067635 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature